Structure and Function of Voltage-gated Ion Channels
نویسنده
چکیده
STRUCTURE AND FUNCTION OF SODIUM CHANNEL SUBUNITS .. . . . . . . . . . 495 Purification and Characterization ....... , . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . 495 Cloning and Primary Structure of the Sodium Channel a Subunit. . . . . . . . . . . . . . . 496 Cloning and Primary Structure of the {Jl and {32 Subunits. . . . . . . . . . . . . . . . . . . . . 498 Functional Role of Na+ Channel Subunits. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 500 Mechanism of Action of pl Subunits. . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . 501
منابع مشابه
Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملInherited disorders of voltage-gated sodium channels.
A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been traced to mutations in genes encoding voltage-gated sodium channels. Clinical severity among these conditions ranges from mild or even latent disease to life-threatening or incapacitating conditions. The sodium channelopathies were among the first recognized ion chan...
متن کاملCurrent and Potential Antiarrhythmic Drugs Targeting Voltage-Gated Cardiac Ion Channels
Voltage-gated ion channels play a fundamental role in the generation and propagation of the cardiac action potential by acting synergistically to produce an ionic current across cellular membranes. Abnormalities of heart ion channel activities that lead to loss or gain of function (channelopathies) are often associated with disruption of the coordinated propagation of electrical activity of the...
متن کاملDeep Insight Section
Ion channels are pore-forming proteins and their function is to facilitate the diffusion of ion across cell membranes by flow of ions down the electrochemical gradient. Voltage-gated ion channels are a class of transmembrane ion channels and are found throughout the body which allowed a rapid and coordinated depolarization in response to voltage change in excitable cells (Catterall, 2010). Rece...
متن کاملPyrethroids and Their Effects on Ion Channels
Ion channels are integral membrane proteins that are critical for neuronal function. They form pores in the plasma membrane that allow certain ions to travel with their concentration gradient across the membrane. Those that open in response to a change in membrane potential are called voltage-gated ion channels. Channels that open in response to binding by a chemical signal or molecule are liga...
متن کاملGating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.
Protein toxins from venomous animals exhibit remarkably specific and selective interactions with a wide variety of ion channels. Hanatoxin and grammotoxin are two related protein toxins found in the venom of the Chilean Rose Tarantula, Phrixotrichus spatulata. Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits voltage-gated Ca2+ channels. Both toxins inhibit their respective ...
متن کامل